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Infrastructure for Personalized Medicine at Partners HealthCare.

Partners HealthCare Personalized Medicine (PPM) is central in partner systems HealthCare (founded by Massachusetts General Hospital and Brigham and Women's Hospital) whose mission is to utilize genetics and genomics to improve patient care in a cost effective manner.

 PPM consists of five interrelated Equine Clia Kitscomponents: (1) Laboratory of Molecular Medicine (LMM), CLIA laboratories perform genetic testing for patients around the world; (2) Translational Genomics Core (TGC), a core lab provides a platform for researchers Partners genome; (3) Options Biobank, a Biobank samples (DNA, plasma and serum) for 50,000 patients agree Partners; (4) Biobank Portal, IT infrastructure and the viewer to unify genotype, sample, phenotype (validated diagnosis, radiology, and clinical chemistry) of electronic medical records researchers Partners. These components are held together by (5) common IT system that brings researchers, clinicians, and patients together for optimal research and patient care.
Infrastructure for Personalized Medicine at Partners HealthCare.

Monitoring the process of measles elimination by serosurveillance data: The study Apulian 2012.


In 2003 Italy adopted a National Plan for the Elimination of Measles and Congenital Rubella, but some outbreaks of measles still occur, as the levels of target coverage (≥ 95%) of newborns General Clia Kits has not currently reached. In order to support the monitoring of measles elimination program, the authors conducted a survey on the seroprevalence of measles among young adults Apulia. This study was conducted from May 2011 to June 2012 among blood donors the Department of Transfusion Medicine General Hospital Policlinico di Bari. Subjects were enrolled by convenience sampling. For each patient enrolled we collect 5 mL serum sample. 

Collected sera were tested by chemiluminescence (CLIA) for anti-measles IgG. We enrolled 1764 subjects; 1362 (77.2%) were male with a mean age of 38.4 ± 11.7 years. Anti-measles IgG titer is >> 16.5UA / mL in 95.1% (95% CI = 94.1 to 96.1) of subjects enrolled with Geometric Mean Titre (GMT) 2.3 ± 0.4, which is not divide different registered till the age groups. As our data show, the universal routine vaccinations changing epidemiological pattern in adults, particularly young adults (18-24 years), which indicates the level of the lowest seropositivity; in groups of people there is a risk of outbreaks because of the presence of vulnerable population. 

It is a paradox associated with vaccination strategy: when the level of coverage keep sub-optimal, measles is more likely to affect young adults and a higher percentage of complications are expected. According to our data, health authorities should plan mop-up strategy to actively offer measles vaccination for young adults who are vulnerable.
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